Treatment

We recommend RetroMAD1 for cats which are experiencing Feline Chronic Gingivostomatitis (FCGS) and not Periodontal Disease.

If the condition is chronic and your cat has not responded to antibiotic treatment, it is highly likely the FCGS is caused by a virus, of which Feline Calicivirus (FCV) is the most common.

RetroMAD1 can be administered as follows:

1a) By Oral Route:

• Dose = 0.50ml per kg, 30 – 45 minutes before a meal, food supplement or probiotics for optimal absorption.
• Daily = 3 times a day with intervals not more than 12 hours apart, e.g. 7AM – 1PM – 7PM, 8AM – 5PM – 11PM. It may be a schedule that is convenient to you, however, please keep to the schedule.

1b) By Subcutaneous Injection:

• Dose = 0.50ml per kg. Do NOT give intramuscular or intravenous injection.
• Daily = 2 times a day. There is no need to observe any food restriction timing.

You may alternate between Subcutaneous injection and Oral administration whichever is most convenient to you but if given orally, it will be 3 times per day.

2) Duration = 15 days.

3) Review with your veterinarian.

We recommend RetroMAD1 for cats that have been diagnosed with Feline Infectious Peritonitis (FIP) – wet or dry forms.

Retromad1 can be administered as follows:

1) By sub-cutaneous injection:

• Dose: 0.50ml per kg. Do NOT give intramuscular or intravenous injection.
• Daily: 2 times a day. There is no meal time restriction.

2) Duration: 20 to 40 days.

3) After 20 days, please visit your veterinarian for a review:

• Medical examination shows improvement in clinical signs.
• CBC and Blood chemistry results.

If you are already treating your cat using GS-441524 / Molnupiravir or have access to GS-441524 / Molnupiravir, you may combine both RetroMAD1 and GS-441524 / Molnupiravir to treat your cat.  We have observed very positive results after only 15 days of the combined treatment.

After the cycle of treatment is completed, you may wish to carry out a PCR-test to see if FCoV can be detected in the blood/serum.

We recommend monitoring asymptomatic FeLV cats regularly by conducting a Complete Blood Count (CBC) including Reticulocyte count, and observing for early signs like gingivitis, stomatitis quarterly. If the results trend downwards, then you can begin treatment with RetroMAD1.

However, if you would like to start treating your cat while it is asymptomatic, then RetroMAD1 can be administered as follows:

• Dose: Ideally 0.30ml per kg, 30 – 45 minutes before a meal, food supplement or probiotics for optimal absorption.
• Daily: 2 times a day with intervals not more than 12 hours apart.

2) Duration: It is not determinable how long it may take for a FeLV-positive cat to become FeLV-negative. The shortest time has been 3 months but we are aware some customers have treated their asymptomatic cats for a few years (with dosage reducing to 0.15mL per kg) while their cats continue to be FeLV-positive. The intent is to ensure that the cat remains asymptomatic throughout so as to lead a normal and active life. Alternatively, you may wish to consider keeping the 30ml Starter Pack on standby so that RetroMAD1 can be given quickly in the event symptoms develop one day.

We recommend RetroMAD1 for FIV cats that are symptomatic and/or CBC (Complete Blood Count; Haematology) parameters are below their respective normal ranges.

Retromad1 can be administered as follows:

1a) By Oral Route:

• Dose: 0.30ml per kg, 30 – 45 minutes before a meal, food supplement or probiotics for optimal absorption.
• Daily: 3 times a day with intervals not more than 12 hours apart, e.g. 7AM – 1PM – 7PM, 8AM – 5PM – 11PM. It may be a schedule that is convenient to you, however, please keep to the schedule.

1b) By Subcutaneous Injection:

• Dose: 0.30ml per kg. Do NOT give intramuscular or intravenous injection.
• Daily: 2 times a day. There is no need to observe any food restriction timing.

2) Duration: 90 days. You may alternate between Subcutaneous injection and Oral administration whichever is most convenient to you but if given orally, it will be 3 times per day.

We recommend monitoring asymptomatic FIV cats regularly by undergoing medical examination and Complete Blood Count (CBC) test and observing for early signs like gingivitis, stomatitis quarterly. Should there be an onset of symptoms or a downward trend in the CBC parameters, then you can begin treatment with RetroMAD1.

However, if you would like to treat your cat while it is asymptomatic, then RetroMAD1 can be administered as follows:

1) By Oral Route:

• Dose: Ideally 0.30ml per kg, 30 – 45 minutes before a meal, food supplement or probiotics for optimal absorption.
• Daily: 2 times a day with intervals not more than 12 hours apart.

2) Duration: FIV is for life and there is no known cure for the disease. We are aware some customers have treated their asymptomatic cats for a few years (with dosage reducing to 0.15mL per kg) while their cats continue to be FIV-positive. The intent is to ensure that the cat remains asymptomatic throughout so as to lead a normal and active life. Alternatively, you may wish to consider keeping the 30ml Starter Pack on standby so that RetroMAD1 can be given quickly in the event symptoms develop one day.

We recommend RetroMAD1 for cats that have been diagnosed with Feline Calicivirus (FCV).

RetroMAD1 can be administered as follows:

1a) By Oral Route:

• Dose: 0.50ml per kg, 30 – 45 minutes before a meal, food supplement or probiotics for optimal absorption.
• Daily: 3 times a day with intervals not more than 12 hours apart, e.g. 7AM – 1PM – 7PM, 8AM – 5PM – 11PM. It may be a schedule that is convenient to you, however, please keep to the schedule.

1b) By sub-cutaneous injection :

• Dose: 0.50ml per kg. Do NOT give intramuscular or intravenous injection.
• Daily: 2 times a day. There is no need to observe any food restriction timing.

You may alternate between Subcutaneous injection and Oral administration whichever is most convenient to you but if given orally, it will be 3 times per day.

2) Duration: 15 days. 15 days to treat the symptoms of FCV infection, but this may not eliminate the virus altogether (we have a few cases where a combination of RetroMAD1 with interferon omega resulted in the cat becoming FCV PCR-negative after becoming asymptomatic).

3) Review with your veterinarian.